Personalized Nutrition: What Your Genome and Gut Biome Reveal Together

Two patients following identical diets will experience meaningfully different glycaemic responses, weight trajectories, and micronutrient absorption profiles. The reasons are encoded in their genomes and microbiomes.

Genomic Influences on Nutrition

• MTHFR variants affect folate metabolism and methylation capacity.
• FTO and MC4R variants influence appetite regulation and obesity risk.
• LCT gene variants determine lactase persistence and tolerance to dairy.
• FADS1/FADS2 variants affect omega-3 fatty acid conversion efficiency.
• VDR variants influence vitamin D receptor sensitivity and requirements.

Microbiome Influences on Nutritional Response

The landmark Weizmann Institute study demonstrated that glycaemic response to identical foods varied dramatically between individuals, driven primarily by differences in gut microbiome composition. When practitioners have access to both genomic and microbiome data, nutritional counselling becomes genuinely personalised — calibrated to the patient's actual biological architecture.